![]() The diagnosis for ASD was made according to the Diagnostic and Statistical Manual of Mental Disorders (4 th edition) text revision (DSM-IV-TR) and was made by an experienced clinician. Twenty-one male children diagnosed with ASD and 15 age-matched typically developing control males (TD) were recruited at the Osaka University Hospital ( Table 1). In order to clarify the differential time-course responses of the primary auditory cortex to repeated sounds, we examined M50/M100 responses in individuals with ASD and analyzed these responses in relation to those in patients with characteristic traits of auditory hypersensitivity. Interestingly, in patients having schizophrenia with sensory abnormalities, P50 event-related potential responses are not diminished by repeated sound stimuli. reported that infants at high risk for autism show less habituation to repeated sounds compared with those at low risk and they speculated that this reduced habituation could be associated with hyposensitivity or over-reactivity to repeated stimulation. We concluded that these phenomena possibly resulted from neurological immaturity or functional abnormalities in the primary auditory cortex. M50/M100 peak responses are activated by auditory stimuli, which responses reflect the process of sensory input and originate in or near the primary auditory cortex. ![]() We recently reported that auditory hypersensitivity in ASD is strongly correlated with delayed M50/M100 peak latencies as well as with increased M50 dipole moments. There are very few clinical interventions available for the treatment of auditory hypersensitivity and, also, the underlying physiological mechanism has yet to be elucidated. These individuals perceive innocuous sounds as painful and frightening noise and in some cases, those sounds may be perceived as phobic stimuli and result in radical behavioral responses in autism spectrum individuals. Unusual perceptual abilities are also common in ASD for example, many individuals with ASD express extreme reactions to at least one sensory modality, such as auditory stimulation. In the Diagnostic and Statistical Manual of Mental Disorders (5th edition), in addition to those classical features, sensory abnormalities were appended to the diagnostic criteria for ASD. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Īutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by qualitative impairments in social interaction and communication, as well as by restricted behavior and interests. 23591494) from Ministry of Education, Culture, Sports, Science and Technology (MEXT). This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This study was supported by a grant-in-aid for scientific research (No. Received: NovemAccepted: JPublished: July 23, 2014Ĭopyright: © 2014 Matsuzaki et al. PLoS ONE 9(7):Įditor: Alexandra Key, Vanderbilt University, United States of America (2014) Progressively Increased M50 Responses to Repeated Sounds in Autism Spectrum Disorder with Auditory Hypersensitivity: A Magnetoencephalographic Study. ![]() Citation: Matsuzaki J, Kagitani-Shimono K, Sugata H, Hirata M, Hanaie R, Nagatani F, et al. ![]()
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